Recent studies have shown that H₂S has the potential to protect the heart against myocardial infarction, arrhythmia, hypertrophy, fibrosis, ischemia-reperfusion injury, and heart failure. Some mechanisms, such as antioxidative action, preservation of mitochondrial function, reduction of apoptosis, anti-inflammatory responses, angiogenic actions, regulation of ion channel, and interaction with NO, could be responsible for the cardioprotective effect of H₂S. Although several mechanisms have been identified, there is a need for further research to identify the specific molecular mechanism of cardioprotection in different cardiac diseases. Therefore, insight into the molecular mechanisms underlying H₂S action in the heart may promote the understanding of pathophysiology of cardiac diseases and lead to new therapeutic targets based on modulation of H₂S production.1
In the cardiovascular system, H₂S is involved in the regulation of vascular tone and blood pressure, inhibits atherogenesis, and protects myocardium from ischemia-reperfusion injury.2
- Shen Y, Shen Z, Luo S, Guo W, Zhu YZ. The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From
Molecular Mechanisms to Therapeutic Potential. Oxid Med Cell Longev. 2015;2015:925167
- Bełtowski J, Jamroz-Wiśniewska A, Tokarzewska D. Hydrogen sulfide and its modulation in arterial hypertension and
atherosclerosis. Cardiovasc Hematol Agents Med Chem. 2010 Oct 1;8(4):173-86.