• H₂S has been reported to exert vasodilatory, antioxidant, antiapoptotic and anti-inflammatory actions and has been shown to act as a signalling molecule, neuromodulator and cytoprotectant. Intriguingly, H₂S has been reported to regulate cell cycle and survival in healthy cells which suggests that it may regulate cell fate and hence the ageing process.1
  • Substantial evidence shows that H₂S is involved in aging by inhibiting free-radical reactions, activating SIRT1, and probably interacting with the age-related gene Klotho. Moreover, H₂S has been shown to have therapeutic potential in age-associated diseases.2
  • Ageing diabetic mouse model developed diabetic cardiomyopathy and that H₂S levels were reduced in the diabetic heart due to alterations in three H₂S -producing enzymes, which may be involved in the pathogenesis of diabetic cardiomyopathy.3
  • The presence of exogenous H₂S from a donor (Na2S.9H2O) significantly suppressed the manifestations of aging, reversed the effects of inhibitors and resulted in the complete suppression of oocyte fragmentation. Cultivation of aging oocytes in the presence of H₂S donor positively affected their subsequent embryonic development following parthenogenetic activation.4
  • Aim to investigate the attenuation of endothelial cell senescence by H₂S and to explore the mechanisms underlying the anti-aging effects of H₂S . Study demonstrated that H₂S protects against HUVEC senescence, potentially through modulation of SIRT1 activity. Furthermore, this study establishes a novel endothelial protective effect of H₂S.5
  • H₂S may have potentially anti-aging effects through the inhibition of AGEs formation and reduction of oxidative stress.6
  • Novel pharmacological agents based on the principle of H₂S donation may be able to retard the onset of age-related disease by slowing the aging process. Results show that H₂S is an endogenous regulator of oxidative damage, metabolism, and aging in C. elegans and provide new insight into the mechanisms, which control aging.7